At the end of the 16th century, England and Spain are locked in a struggle for control of the world. Eventually, they come to learn of the existence of special stones known as Amrita, which contain a unique spiritual power that can mean the difference between victory and defeat.
With the Liefde moored offshore, William takes a small skiff to the island's sandy shores. Upon his arrival, he sees some corpses belongong to the island's natives, their bodies covered with some kind of grotesque creatures.
The group departs the harbour well-stocked thanks to supplies from the grateful Kuroda clan, and the Liefde sets sail for the Kinki region. Along the way, the ship is attacked by a giant Oni known as an Umi-Bozu. It narrowly avoids disaster, but suffers heavy damage and is forced to seek refuge in a port in the Chugoku region.
The blond-haired blue-eyed samurai William once again attempting to make landfall in Japan. While in London, he had somehow foreseen that Hanzo may be in danger. Soon after, he is reunited with Nekomata who joins him as his Guardian Spirit.